Alzheimer's disease pathology and the unfolded protein response : Prospective pathways and therapeutic targets

The authors would like to thank Alzheimer's Research UK (Grant refs: ARUK-PPG2014A-21 and ARUK-NSG2015-1 to BP and DK) who have provided support for relevant projects leading to this review.Peer reviewedPostprin

Zeroes of partial sums of the zeta-function

This article considers the positive integers $N$ for which $\zeta_{N}(s) = \sum_{n=1}^{N} n^{-s}$ has zeroes in the half-plane $\Re(s)>1$. Building on earlier results, we show that there are no zeroes for $1\leq N\leq 18$ and for $N=20, 21, 28$. For all other $N$ there are infinitely many zeroes.Comment: 5 Pages - Final Version will appear in LMS JC

The effects on health of a publicly funded domestic heating programme: a prospective controlled study

<b>Objective</b>: To assess the effect of a publicly funded domestic heating programme on self-reported health. <b>Design, setting and participants</b>: A prospective controlled study of 1281 households in Scotland receiving new central heating under a publicly funded initiative, and 1084 comparison households not receiving new heating. The main outcome measures were self-reported diagnosis of asthma, bronchitis, eczema, nasal allergy, heart disease, circulatory problems or high blood pressure; number of primary care encounters and hospital contacts in the past year; and SF-36 Health Survey scores. <b>Results</b>: Usable data were obtained from 61.4% of 3849 respondents originally recruited. Heating recipients reported higher scores on the SF-36 Physical Functioning scale (difference 2.51; 95% CI 0.67 to 4.37) and General Health scale (difference 2.57; 95% CI 0.90 to 4.34). They were less likely to report having received a first diagnosis of heart disease (OR 0.69; 95% CI 0.52 to 0.91) or high blood pressure (OR 0.77; 95% CI 0.61 to 0.97), but the groups did not differ significantly in use of primary care or hospital services. <b>Conclusions</b>: Provision of central heating was associated with significant positive effects on general health and physical functioning; however, effect sizes were small. Evidence of a reduced risk of first diagnosis with heart disease or high blood pressure must be interpreted with caution, due to the self-reported nature of the outcomes, the limited time period and the failure to detect any difference in health service use

Advanced Microwave Precipitation Radiometer (AMPR) for remote observation of precipitation

The design, development, and tests of the Advanced Microwave Precipitation Radiometer (AMPR) operating in the 10 to 85 GHz range specifically for precipitation retrieval and mesoscale storm system studies from a high altitude aircraft platform (i.e., ER-2) are described. The primary goals of AMPR are the exploitation of the scattering signal of precipitation at frequencies near 10, 19, 37, and 85 GHz together to unambiguously retrieve precipitation and storm structure and intensity information in support of proposed and planned space sensors in geostationary and low earth orbit, as well as storm-related field experiments. The development of AMPR will have an important impact on the interpretation of microwave radiances for rain retrievals over both land and ocean for the following reasons: (1) A scanning instrument, such as AMPR, will allow the unambiguous detection and analysis of features in two dimensional space, allowing an improved interpretation of signals in terms of cloud features, and microphysical and radiative processes; (2) AMPR will offer more accurate comparisons with ground-based radar data by feature matching since the navigation of the ER-2 platform can be expected to drift 3 to 4 km per hour of flight time; and (3) AMPR will allow underflights of the SSM/I satellite instrument with enough spatial coverage at the same frequencies to make meaningful comparisons of the data for precipitation studies

Opposing shear senses in a subdetachment mylonite zone: Implications for core complex mechanics

[1] Global studies of metamorphic core complexes and low‐angle detachment faults have highlighted a fundamental problem: Since detachments excise crustal section, the relationship between the mylonitic rocks in their footwalls and the brittle deformation in their hanging walls is commonly unclear. Mylonites could either reflect ductile deformation related to exhumation along the detachment fault, or they could be a more general feature of the extending middle crust that has been “captured ” by the detachment. In the first case we would expect the kinematics of the mylonite zone to mirror the sense of movement on the detachment; in the second case both the direction and sense of shear in the mylonites could be different. The northern Snake Range décollement (NSRD) is a classic Basin and Range detachment fault with a well‐documented top‐east of displacement. We present structural, paleo-magnetic, geochronological, and geothermometric evidence to suggest that the mylonite zone below the NSRD locally experienced phases of both east ‐ and west‐directed shear, inconsistent with movement along a single detachment fault. We therefore propose that the footwall mylonites represent a predetachment dis-continuity in the middle crust that separated localized deformation above from distributed crustal flow below (localized‐distributed transition (LDT)). The mylonites were subsequently captured by a moderately dipping brittle detachment that soled down to the middle crust and exhumed them around a rolling hinge into a subhorizontal orientation at the surface, produc-ing the present‐day NSRD. In this interpretation the brittle hanging wall represents a series of rotated upper crustal normal faults, whereas the mylonitic footwall represents one or more exhumed middl

Holographic and ultrasonic detection of bond flaws in aluminum panels reinforced with boron-epoxy

An experimental investigation was made of the application of holographic interferometry to the nondestructive detection of unbonded areas (flaws) in bonded panels. Flaw detection results were compared with results obtained with an ultrasonic flaw detector. Holography, with panel deformation accomplished by a reduction in ambient pressure, is less sensitive for flaws beneath 5 and 10 plies of boron-epoxy than the ultrasonic method, though it does have its operational advantages. A process for the manufacture of bonded panels which incorporate known unbonded areas was also developed. The unbonded areas were formed without the use of foreign materials, which makes the method suitable for the construction of reference standards for bonded panels whenever needed for the proper setup of ultrasonic flaw-detection instruments

Climatic controls on diatom succession at Elk Lake, Minnesota [abstract]

EXTRACT (SEE PDF FOR FULL ABSTRACT): Sediment traps placed in the profundal region of Elk Lake, north central Minnesota during the 1979 spring and 1983-84 fall and spring seasons monitored seasonal diatom production for two climatically distinctive periods